Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | GAA | P10253 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | PABPC1 | P11940 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | FGB | P02675 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22879389 | 0.74 | GAA (0.59) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL6545369 | 0.74 | MAPT (0.59) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL12463182 | 0.71 | L3MBTL1 (0.66) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL12462878 | 0.71 | L3MBTL1 (0.66) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL16268747 | 0.68 | GAA (0.63) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL2279059 | 0.68 | GAA (0.51) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL9628939 | 0.66 | NPC1 (0.53) | MAPTGAAMEN1KMT2APABPC1 | |
| SCHEMBL4293844 | 0.66 | MEN1 (0.59) | MAPTGAAMEN1KMT2APABPC1 | |
| Phenothiazine SCHEMBL9114 | 0.65 | NOX1 (1.00) | MAPTGAAMEN1KMT2ANPSR1 | |
| Phenothiazine SCHEMBL2504207 | 0.65 | NOX1 (1.00) | MAPTGAAMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027055-B1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2004-01-07 | — | — | EP | disclosed |
| EP-1027055-A4 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1027055-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5994349-A | ANTIEPILEPTIC AGENTS | HOWARD UNIVERSITY (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999021560-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4[10H]-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 1999-05-06 | — | — | WO | disclosed |