Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | PCNA | P12004 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28179550 | 0.96 | SLC7A5 (0.51) | SLC7A5ITGA4ALOX15BLMPMP22 | |
| Tyrosine SCHEMBL18339169 | 0.93 | SLC7A5 (0.44) | SLC7A5ITGA4ALOX15BLMPMP22 | |
| Tyrosine SCHEMBL6665573 | 0.92 | SLC7A5 (0.56) | SLC7A5ITGA4ALOX15ITGB1DPP4 | |
| Tyrosine SCHEMBL1826640 | 0.89 | SLC7A5 (0.52) | SLC7A5ITGA4ALOX15ITGB1DPP4 | |
| Tyrosine SCHEMBL20575032 | 0.89 | SLC7A5 (0.52) | SLC7A5ITGA4ALOX15ITGB1DPP4 | |
| Phenylalanine SCHEMBL15901818 | 0.88 | SLC7A5 (0.49) | SLC7A5ALOX15BLMPMP22KMT2A | |
| Tyrosine SCHEMBL4205061 | 0.87 | SLC7A5 (0.61) | SLC7A5ITGA4ALOX15PMP22KMT2A | |
| Tyrosine SCHEMBL4205059 | 0.87 | SLC7A5 (0.61) | SLC7A5ITGA4ALOX15PMP22KMT2A | |
| Tyrosine SCHEMBL4352800 | 0.87 | SLC7A5 (0.61) | SLC7A5ITGA4ALOX15PMP22KMT2A | |
| Tyrosine SCHEMBL5152642 | 0.87 | SLC7A5 (0.61) | SLC7A5ITGA4ALOX15PMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034187-B1 | GROWTH-PROMOTING PROTEINS AND PEPTIDES FOR KIDNEY EPITHELIAL CELLS | ARCH DEV CORP (US) | 2004-01-07 | — | — | EP | claimed |