Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 15/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 15/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994638 | 0.93 | MME (0.40) | AGTR1AGTR2MME | |
| SCHEMBL656100 | 0.91 | AGTR2 (0.43) | AGTR1AGTR2 | |
| SCHEMBL654478 | 0.88 | MME (0.39) | MME | |
| SCHEMBL994156 | 0.87 | MME (0.42) | AGTR1AGTR2MME | |
| SCHEMBL656184 | 0.84 | AGTR2 (0.42) | AGTR2MME | |
| SCHEMBL656183 | 0.84 | AGTR2 (0.42) | AGTR2MME | |
| SCHEMBL1927460 | 0.84 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL1075898 | 0.83 | AGTR1 (0.41) | AGTR1AGTR2MME | |
| SCHEMBL996269 | 0.83 | AGTR1 (0.41) | AGTR1AGTR2MME | |
| SCHEMBL651016 | 0.83 | MME (0.43) | AGTR1AGTR2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119634-B2 | Dual-acting pyrazole antihypertensive agents | THERAVANCE, INC. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110009409-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009409-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | AGTR1, AGTR2, REN | AGTR1 1/4885AGTR2 2/4885MME 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.