Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860995 | 0.76 | HPGD (0.47) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL2869259 | 0.74 | MAPK8 (0.39) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL2872869 | 0.73 | ROCK2 (0.50) | LMNAGSK3B | |
| SCHEMBL13636075 | 0.70 | CDK4 (0.47) | PARP1CDK4CCND1CDK2CCNA2 | |
| SCHEMBL2865008 | 0.69 | CSNK1D (0.44) | KDRCHEK2JAK2 | |
| SCHEMBL2861275 | 0.69 | CA12 (0.50) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL2864472 | 0.68 | IKBKB (0.43) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL2867285 | 0.67 | ITK (0.45) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL4334282 | 0.66 | SCN9A (0.39) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL2870025 | 0.66 | ROCK2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-A1 | NOVEL 1H-INDAZOLE COMPOUND | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |