Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606996 | 0.78 | ALDH1A1 (0.31) | ALDH1A1KMT2ASRC | |
| SCHEMBL14355500 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KMT2ASRC | |
| SCHEMBL8604697 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL310073 | 0.69 | — | — | |
| SCHEMBL332354 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KMT2ASRC | |
| SCHEMBL14355501 | 0.67 | ALDH1A1 (0.47) | ALDH1A1KMT2ASRC | |
| SCHEMBL11036281 | 0.67 | ALDH1A1 (0.57) | ALDH1A1KMT2ASRC | |
| SCHEMBL7829339 | 0.65 | HSD17B10 (0.40) | ALDH1A1SRC | |
| SCHEMBL14355486 | 0.65 | GABBR2 (0.47) | ALDH1A1 | |
| SCHEMBL9810499 | 0.65 | ALDH1A1 (0.36) | ALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021528-B1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | INST GENETICS LLC (US) | 2004-01-28 | — | — | EP | claimed |
| US-6593106-B1 | Culturing prokaryotic cells which have been transformed with a DNA encoding a transforming growth factor protein; substituted pyrroles; useful in preparation of bone morphogenetic proteins | GENETICS INSTITUTE LLC | 2003-07-15 | — | — | US | claimed |
| US-20020052026-A1 | METHODS OF REFOLDING PROTEINS | GENETICS INSTITUTE, LLC | 2002-05-02 | — | — | US | claimed |
| EP-1021528-A1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | GENETICS INSTITUTE, INC. (US) | 2000-07-26 | — | — | EP | claimed |
| WO-1999018196-A1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | GENETICS INSTITUTE, INC. (US) | 1999-04-15 | — | — | WO | claimed |
| EP-1021528-B1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | INST GENETICS LLC (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6632635-B1 | Useful in improved processes for preparation of biologically active dimeric recombinant bone morphogenetic proteins using acid substituted aminocyclohexanes | GENETICS INSTITUTE | 2003-10-14 | — | — | US | disclosed |
| US-6596511-B1 | Expression of transforming growth factor protein; culture prokaryotic cells containing sequences coding transforming growth factor, express nucleotide sequences, fold protein in fluid containing trigonelline hydrochloride | GENETICS INSTITUTE LLC | 2003-07-22 | — | — | US | disclosed |
| US-6593107-B1 | Culturing prokaryotic cells which have been transformed with a DNA encoding a transforming growth factor; pyridine 3-sulfonic acid; useful in preparation of bone morphogenetic proteins | GENETICS INSTITUTE LLC | 2003-07-15 | — | — | US | disclosed |
| US-6593106-B1 | Culturing prokaryotic cells which have been transformed with a DNA encoding a transforming growth factor protein; substituted pyrroles; useful in preparation of bone morphogenetic proteins | GENETICS INSTITUTE LLC | 2003-07-15 | — | — | US | disclosed |
| US-20020052026-A1 | METHODS OF REFOLDING PROTEINS | GENETICS INSTITUTE, LLC | 2002-05-02 | — | — | US | disclosed |
| EP-1021528-A1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | GENETICS INSTITUTE, INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018196-A1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | GENETICS INSTITUTE, INC. (US) | 1999-04-15 | — | — | WO | disclosed |