Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6547714 | 0.91 | PLA2G4B (0.45) | PLA2G4AS1PR4S1PR1S1PR3PLA2G4B | |
| SCHEMBL6548899 | 0.87 | SCN9A (0.48) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL6548487 | 0.77 | DPP4 (0.49) | ALDH1A1SMN1; SMN2MEN1USP2LMNA | |
| SCHEMBL6547146 | 0.75 | DPP4 (0.45) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL7869779 | 0.75 | NPC1 (0.53) | PLA2G4APLA2G4BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7870492 | 0.74 | NPC1 (0.52) | PLA2G4APLA2G4BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1333578 | 0.73 | LTA4H (0.56) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL833843 | 0.73 | LTA4H (0.56) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL8571707 | 0.73 | LTA4H (0.56) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 | |
| SCHEMBL1756468 | 0.73 | LTA4H (0.56) | ALDH1A1SMN1; SMN2MEN1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204714-B1 | BI-OR TERTHIENYL SUBSTITUTED PHOTOCHROMIC NAPHTHO 2,1-B]PYRAN COMPOUNDS | ESSILOR INT (FR) | 2004-01-28 | — | — | EP | disclosed |
| EP-1204714-A1 | BI-OR TERTHIENYL SUBSTITUTED PHOTOCHROMIC NAPHTHO 2,1-B]PYRAN COMPOUNDS | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001004233-A1 | BI-OR TERTHIENYL SUBSTITUTED PHOTOCHROMIC NAPHTHO[2,1-B]PYRAN COMPOUNDS | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2001-01-18 | — | — | WO | disclosed |