SCHEMBL6547273

SCHEMBL6547273

CC(=NOCc1ccccc1)c1ccc(COc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
S1PR1 P21453 2/20 0.39
PPARG P37231 7/20 0.38
PPARA Q07869 5/20 0.38
NR1H4 Q96RI1 2/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 2/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
HPGD P15428 1/20 0.35
GLRA1 P23415 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6549405 0.92 NPC1 (0.35) NPC1RAB9AL3MBTL1SMN1; SMN2S1PR1
SCHEMBL6549004 0.91 NPC1 (0.35) NPC1RAB9AL3MBTL1SMN1; SMN2PPARG
SCHEMBL6548842 0.87 HRH3 (0.43) LMNAHTT
SCHEMBL6547677 0.87 SMN1; SMN2 (0.33) NPC1RAB9AL3MBTL1SMN1; SMN2PPARG
SCHEMBL6549656 0.86 ESR1 (0.36) NPC1RAB9AL3MBTL1SMN1; SMN2S1PR1
SCHEMBL6549867 0.85 HTT (0.36) PPARGKDM4ELMNAHTT
SCHEMBL6548809 0.84 HTT (0.33) NPC1RAB9ASMN1; SMN2HTTGLRA1
SCHEMBL6547607 0.84 HTT (0.33) HTT
SCHEMBL8408601 0.84 KDM4E (0.41) NPC1RAB9ASMN1; SMN2S1PR1PPARG
SCHEMBL8657017 0.82 LMNA (0.45) NPC1RAB9AL3MBTL1SMN1; SMN2S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975586-B1 OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2004-12-01 EP disclosed
US-6448444-B2 INSECTICIDES, MITICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-10 US disclosed
US-6437184-B1 INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-08-20 US disclosed
US-20020019569-A1 Oxime compounds, their use, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED 2002-02-14 US disclosed
EP-0975586-A2 OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION Sumitomo Chemical Company, Limited (JP) 2000-02-02 EP disclosed
WO-1998045254-A2 OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-10-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019569-A1 Oxime compounds, their use, and intermediates for their production CBR3, CBR1, NOX3 NPC1 1404/4885RAB9A 2309/4885L3MBTL1 876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.