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Arginine

Arginine

SCHEMBL6547494

C[C@H](N)C(=O)OC[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1.C[C@H](N)C(=O)O[C@H](C)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 9/20 0.34
▸ NPY1R P25929 6/20 0.34
▸ NPY2R P49146 4/20 0.32
▸ NPY5R Q15761 4/20 0.32
▸ SLC7A5 Q01650 1/20 0.32
▸ ITGB3 P05106 2/20 0.31
▸ ITGA2B P08514 2/20 0.31
▸ PRSS1 P07477 7/20 0.31
▸ TMPRSS15 P98073 7/20 0.31
▸ THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lysine SCHEMBL6547077 0.89 ITGB3 (0.39) ITGB3ITGA2BTHRB
Glutamic Acid SCHEMBL6546960 0.88 ITGB3 (0.33) SLC7A5ITGB3ITGA2BTHRB
Glutamic Acid SCHEMBL8428095 0.81 NPY4R (0.38) NPY4RNPY1RNPY2RNPY5R
Aspartic Acid SCHEMBL10457651 0.80 SLC7A5 (0.39) NPY4RNPY1RNPY2RNPY5RSLC7A5
Glycine SCHEMBL5579222 0.79 ITGB3 (0.45) NPY4RNPY1RNPY2RNPY5RSLC7A5
Arginine SCHEMBL8468543 0.78 NPY4R (0.35) NPY4RNPY1RNPY2RNPY5RSLC7A5
Tyrosine SCHEMBL27938695 0.78 SLC7A5 (0.47) NPY4RNPY1RNPY2RNPY5RSLC7A5
Glycine SCHEMBL9511974 0.77 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RSLC7A5
Arginine SCHEMBL9540783 0.77 ITGB3 (0.48) NPY4RNPY1RNPY2RNPY5RSLC7A5
Glutamic Acid SCHEMBL7759812 0.76 NPY4R (0.42) NPY4RNPY1RNPY2RNPY5RSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767381-B1 Detection, quantification and classification of ras proteins in body fluids and tissues BAYER AG (US) 2004-01-28 — — EP disclosed
US-6200764-B1 MONITORING ACTIVATED G-PROTEIN IN A BODILY FLUID; INCUBATING BODILY FLUID WITH AN IMMOBILIZED MONOCOLNAL ANTIBODY, SCREEN FOR SIGNAL IN SAMPLE BAYER CORPORATION 2001-03-13 — — US disclosed
EP-0411018-B1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES ONCOGENE SCIENCE INC (US) 1997-06-04 — — EP disclosed
EP-0767381-A1 Detection, quantification and classification of ras proteins in body fluids and tissues Oncogene Science, Inc. (US) 1997-04-09 — — EP disclosed
EP-0411018-A4 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES — 1991-08-21 — — EP disclosed
EP-0411018-A1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES. DU PONT (US) 1991-02-06 — — EP disclosed
WO-1989010565-A1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-11-02 — — WO disclosed