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Sugi Predict / Compounds / Glutamic Acid

Glutamic Acid

Glutamic Acid

SCHEMBL6546960

CC(C)C[C@H](N)C(=O)O.C[C@H](N)C(=O)OC[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1.C[C@H](N)C(=O)O[C@H](C)[C@H](N)C(=O)O.NCC(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SSTR1SSTR2SSTR3SSTR5

The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ITGB3 P05106 1/20 0.33
▸ ITGA2B P08514 1/20 0.33
▸ PTGS2 P35354 1/20 0.32
▸ PTPN1 P18031 1/20 0.32
▸ ANPEP P15144 1/20 0.31
▸ RNPEP Q9H4A4 1/20 0.31
▸ DNPEP Q9ULA0 1/20 0.31
▸ THRB P10828 1/20 0.31
▸ SLC7A5 Q01650 1/20 0.30
▸ MMP1 P03956 1/20 0.30
▸ MMP2 P08253 1/20 0.30
▸ MMP3 P08254 1/20 0.30
▸ MMP9 P14780 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lysine SCHEMBL6547077 0.92 ITGB3 (0.39) ITGB3ITGA2BPTPN1THRB
Arginine SCHEMBL6547494 0.88 NPY4R (0.34) ITGB3ITGA2BTHRBSLC7A5
Phenylalanine SCHEMBL9279844 0.77 — —
Glutamic Acid SCHEMBL9857957 0.77 PTPN1 (0.47) ITGB3ITGA2BPTGS2PTPN1THRB
Glutamine SCHEMBL8908100 0.75 THRB (0.39) ITGB3ITGA2BPTGS2THRB
D-Glutamate SCHEMBL28632361 0.75 SLC1A3 (0.46) SLC7A5
Tyrosine SCHEMBL9751255 0.73 SLC7A5 (0.58) ITGB3ITGA2BPTGS2PTPN1THRB
Glutamic Acid SCHEMBL8428095 0.73 NPY4R (0.38) —
Dl-Phenylalanine SCHEMBL21410030 0.73 SLC7A5 (0.56) ANPEPRNPEPDNPEPSLC7A5
Lysine SCHEMBL1921682 0.72 ITGB3 (0.54) ITGB3ITGA2BPTGS2PTPN1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767381-B1 Detection, quantification and classification of ras proteins in body fluids and tissues BAYER AG (US) 2004-01-28 — — EP disclosed
US-6200764-B1 MONITORING ACTIVATED G-PROTEIN IN A BODILY FLUID; INCUBATING BODILY FLUID WITH AN IMMOBILIZED MONOCOLNAL ANTIBODY, SCREEN FOR SIGNAL IN SAMPLE BAYER CORPORATION 2001-03-13 — — US disclosed
EP-0411018-B1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES ONCOGENE SCIENCE INC (US) 1997-06-04 — — EP disclosed
EP-0767381-A1 Detection, quantification and classification of ras proteins in body fluids and tissues Oncogene Science, Inc. (US) 1997-04-09 — — EP disclosed