Arginine

SCHEMBL8468543

C[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)OC[C@H](N)C(=O)O)cc1.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)OC(=O)CN.NC(=O)CC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	NPY4R	P50391	9/20	0.35

▸	NPY1R	P25929	6/20	0.35

▸	PRSS1	P07477	9/20	0.33

▸	TMPRSS15	P98073	9/20	0.33

▸	NPY2R	P49146	4/20	0.33

▸	NPY5R	Q15761	4/20	0.33

▸	THRB	P10828	1/20	0.32

▸	SLC7A5	Q01650	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL995485	0.81	NPY4R (0.36)	NPY4RNPY1RPRSS1TMPRSS15NPY2R
Glycine SCHEMBL5344900	0.80	NPY4R (0.38)	NPY4RNPY1RNPY2RNPY5RSLC7A5
SCHEMBL2674971	0.80	NPY4R (0.39)	NPY4RNPY1RNPY2RNPY5RSLC7A5
Glycine SCHEMBL9511974	0.79	NPY4R (0.40)	NPY4RNPY1RPRSS1TMPRSS15NPY2R
Arginine SCHEMBL4405153	0.79	NPY4R (0.36)	NPY4RNPY1RNPY2RNPY5RSLC7A5
Arginine SCHEMBL9540783	0.79	ITGB3 (0.48)	NPY4RNPY1RNPY2RNPY5RTHRB
Arginine SCHEMBL6547494	0.78	NPY4R (0.34)	NPY4RNPY1RPRSS1TMPRSS15NPY2R
Glycine SCHEMBL5579222	0.77	ITGB3 (0.45)	NPY4RNPY1RNPY2RNPY5RSLC7A5
Arginine SCHEMBL8400999	0.77	NPY4R (0.47)	NPY4RNPY1RNPY2RNPY5RSLC7A5
SCHEMBL1231526	0.76	SLC7A5 (0.47)	NPY4RNPY1RNPY2RNPY5RSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5922580-A	CONTACTING A REDUCING PARTIAL STARCH HYDROLYSATE WITH A NOVEL ENZYME WHICH FORMS A NON-REDUCING SACCHARIDE IN THE ABSENCE OF TREHALOSE; GLUCOAMYLASE AND GLYCOSIDASE YIELD TREHALOSE WHEN ALLOWED TO ACT ON THE NON-REDUCING SACCHARIDE	KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP)	1999-07-13	—	—	US	disclosed