Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GABRP | O00591 | 2/20 | 0.52 |
| ▸ | GABRD | O14764 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.52 |
| ▸ | GABRE | P78334 | 2/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL28713732 | 0.93 | OPRM1 (0.61) | OPRM1TP53GABRPGABRDGABRA1 | |
| Oxalic Acid SCHEMBL28713733 | 0.93 | OPRM1 (0.61) | OPRM1TP53GABRPGABRDGABRA1 | |
| Acetic Acid SCHEMBL5571311 | 0.93 | OPRM1 (0.61) | OPRM1TP53GABRPGABRDGABRA1 | |
| Tuaminoheptane SCHEMBL25287775 | 0.93 | OPRM1 (0.76) | OPRM1TP53GABRPGABRDGABRA1 | |
| Tuaminoheptane SCHEMBL8359697 | 0.93 | OPRM1 (0.76) | OPRM1TP53GABRPGABRDGABRA1 | |
| Tuaminoheptane SCHEMBL3365884 | 0.93 | OPRM1 (0.76) | OPRM1TP53GABRPGABRDGABRA1 | |
| Bicarbonate SCHEMBL9188645 | 0.91 | OPRM1 (0.73) | OPRM1TP53SLC1A2SLC1A1CA1 | |
| Adipic Acid SCHEMBL28356792 | 0.87 | GABRP (0.61) | OPRM1GABRPGABRDGABRA1GABRB1 | |
| Cadaverine Tartrate SCHEMBL4889963 | 0.87 | OPRM1 (0.54) | OPRM1TP53GABRPGABRDGABRA1 | |
| Adipic Acid SCHEMBL27884363 | 0.87 | GABRP (0.61) | OPRM1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021528-B1 | METHODS OF REFOLDING PROTEINS BY USE OF ZWITTERIONIC LOW MOLECULAR WEIGHT AGENTS | INST GENETICS LLC (US) | 2004-01-28 | — | — | EP | claimed |