Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797064 | 0.91 | GAA (0.43) | GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL6550804 | 0.89 | LMNA (0.48) | GAAMMP13SMN1; SMN2MAPK1LMNA | |
| SCHEMBL6800743 | 0.89 | LMNA (0.48) | GAAMMP13SMN1; SMN2MAPK1LMNA | |
| SCHEMBL6796275 | 0.86 | KMT2A (0.47) | GAAKMT2ATP53SMN1; SMN2HPGD | |
| SCHEMBL7113849 | 0.84 | PNP (0.43) | MMP13MEN1KMT2ATP53PABPC1 | |
| SCHEMBL7113168 | 0.84 | PNP (0.43) | MMP13MEN1KMT2ATP53PABPC1 | |
| SCHEMBL6550065 | 0.84 | MMP13 (0.42) | GAAMMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL6801426 | 0.84 | MCHR1 (0.39) | GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL6549145 | 0.83 | GAA (0.52) | GAAMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL6548067 | 0.83 | L3MBTL1 (0.47) | GAAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383766-A1 | DISUBSTITUTED 1,7-GUANINES | Pharmacia Italia S.p.A. (IT) | 2004-01-28 | — | — | EP | claimed |
| WO-2002090357-A1 | DISUBSTITUTED 1,7-GUANINES | PHARMACIA ITALIA S.P.A. (IT) | 2002-11-14 | — | — | WO | claimed |