SCHEMBL6549343

SCHEMBL6549343

Cc1cc(C(C)(C)C)c(OP(Cl)c2ccccc2)c(C(C)(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CA2 P00918 1/20 0.36
POLB P06746 1/20 0.36
TYR P14679 1/20 0.36
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
TNFRSF1A P19438 1/20 0.31
HSPA5 P11021 1/20 0.31
TACR1 P25103 1/20 0.31
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
HIF1A Q16665 1/20 0.30
GABRA1 P14867 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11494221 0.92 ALDH1A1 (0.33) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL11488213 0.87 CYP1A2 (0.36) TSHRCYP3A4TNFRSF1ATACR1CYP2C9
SCHEMBL11496623 0.85 CA2 (0.36) ALDH1A1CA2TSHRTDP1GABRA1
SCHEMBL11300513 0.85 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL7884180 0.83 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL2952176 0.79 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2CA2TSHRTDP1
SCHEMBL8634811 0.77 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL9238574 0.77 SMN1; SMN2 (0.45) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL8352457 0.77 SMN1; SMN2 (0.50) ALDH1A1SMN1; SMN2CA2POLBTYR
SCHEMBL14264168 0.76 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2CA2POLBTYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383833-A1 GRANULAR POLYMER ADDITIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 2004-01-28 EP disclosed
EP-1363972-A1 GRANULAR POLYMER ADDITIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 2003-11-26 EP disclosed
US-6515052-B2 Granular polymer additives and their preparation ALBEMARLE CORPORATION 2003-02-04 US disclosed
WO-2002068523-A1 GRANULAR POLYMER ADDITIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 2002-09-06 WO disclosed
WO-2002068524-A1 GRANULAR POLYMER ADDITIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 2002-09-06 WO disclosed
US-20020117651-A1 Granular polymer additives and their preparation ALBEMARLE CORPORATION 2002-08-29 US disclosed
US-4233207-A STABILIZING POLYMERS AGAINST OXIDATION, HEAT, AND RADIATION CIBA-GEIGY CORPORATION (US) 1980-11-11 US disclosed