Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 13/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48824 | 0.76 | ALDH1A1 (0.46) | GPR52MEN1LMNAALDH1A1 | |
| SCHEMBL48831 | 0.75 | PIK3CG (0.64) | PI4KBLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL5508446 | 0.70 | ATAD2 (0.39) | GPR52MEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL2821323 | 0.70 | GAA (0.49) | MEN1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL10995049 | 0.69 | MAPT (0.60) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL11563534 | 0.69 | MEN1 (0.60) | MEN1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL3638579 | 0.67 | ALDH1A1 (0.54) | GPR52MEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5133373 | 0.67 | GAA (0.56) | MEN1PI4KBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL26479600 | 0.67 | ALDH1A1 (0.40) | MEN1PI4KBGRK6ALDH1A1SMN1; SMN2 | |
| SCHEMBL2091031 | 0.66 | TDP1 (0.56) | MEN1LMNAMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480962-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | Novartis AG (CH) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072557-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2003-09-04 | — | — | WO | disclosed |