Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.50 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458240 | 0.86 | OPRD1 (0.59) | KMT2AOPRD1CHEK1TMEM97SIGMAR1 | |
| SCHEMBL7066693 | 0.82 | CHRNA7 (0.51) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL4553991 | 0.81 | OPRD1 (0.54) | KMT2AALDH1A1OPRD1F2PRSS1 | |
| SCHEMBL2232683 | 0.80 | GAA (0.62) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL6698448 | 0.80 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL6550226 | 0.79 | MAPT (0.61) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL3233096 | 0.78 | MEN1 (0.53) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL3128886 | 0.77 | CHRNA7 (0.58) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL7253167 | 0.76 | MEN1 (0.51) | KMT2AMEN1ALDH1A1HTTCHRNA7 | |
| SCHEMBL29696209 | 0.76 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1HTTCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383753-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | claimed |
| WO-2003047575-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | claimed |
| WO-2002083658-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2002-10-24 | — | — | WO | claimed |
| EP-1383753-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2003047575-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048121-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002083658-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2002-10-24 | — | — | WO | disclosed |