Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13970462 | 0.93 | MCHR1 (0.56) | SIGMAR1CHRM4DRD4ABL1RIN1 | |
| SCHEMBL30135747 | 0.88 | CHRM4 (0.53) | CHRM4ABL1RIN1SMN1; SMN2 | |
| SCHEMBL29739590 | 0.88 | S1PR1 (0.50) | CHRM4ABL1RIN1KMT2ASMN1; SMN2 | |
| SCHEMBL10361893 | 0.88 | SIGMAR1 (0.65) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL13102893 | 0.87 | MCHR1 (0.61) | SIGMAR1CHRM4DRD4DRD2DRD3 | |
| SCHEMBL30802295 | 0.85 | SIGMAR1 (0.60) | SIGMAR1DRD4SMN1; SMN2 | |
| SCHEMBL5122686 | 0.84 | TGM2 (0.67) | SIGMAR1DRD4DRD2DRD3KMT2A | |
| SCHEMBL11960651 | 0.83 | ALDH1A1 (0.58) | SIGMAR1DRD2KMT2A | |
| SCHEMBL954965 | 0.83 | KMT2A (0.60) | KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5854461 | 0.81 | ALDH1A1 (0.56) | SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483284-A2 | SELECTIVE DIPEPTIDE INHIBITORS OF KALLIKREIN | Ferring BV (NL) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003076458-A2 | SELECTIVE DIPEPTIDE INHIBITORS OF KALLIKREIN | FERRING BV (NL) | 2003-09-18 | — | — | WO | disclosed |
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |