Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 12/20 | 0.54 |
| ▸ | HTR1B | P28222 | 8/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6551644 | 1.00 | HTR1D (0.57) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6552133 | 1.00 | HTR1D (0.57) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6551704 | 0.90 | HTR1D (0.62) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6551707 | 0.90 | HTR1D (0.62) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6786239 | 0.90 | HTR1D (0.62) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6551568 | 0.90 | HTR1D (0.66) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6552766 | 0.90 | HTR1D (0.66) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6551571 | 0.90 | HTR1D (0.66) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6552907 | 0.85 | HTR1D (0.75) | HTR1DSLC6A4DRD2ADRA1DADRA1A | |
| SCHEMBL6551563 | 0.85 | HTR1D (0.75) | HTR1DSLC6A4DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409476-B1 | PHARMACEUTICAL COMPOUNDS WITH SEROTONIN RECEPTOR ACTIVITY | LILLY CO ELI (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20040180883-A1 | Pharmaceutical compounds with serotonin receptor activity | GILMORE JEREMY (GB) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180883-A1 | Pharmaceutical compounds with serotonin receptor activity | HTR1A, HTR5A, HTR1E | HTR1D 8/4885SLC6A4 33/4885DRD2 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.