SCHEMBL6552210

SCHEMBL6552210

O=C(O)/C=C\c1ccc2ccccc2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.62
HDAC3 O15379 2/20 0.61
HDAC4 P56524 2/20 0.61
HDAC1 Q13547 2/20 0.61
HDAC7 Q8WUI4 2/20 0.61
HDAC2 Q92769 2/20 0.61
HDAC10 Q969S8 2/20 0.61
HDAC11 Q96DB2 2/20 0.61
HDAC8 Q9BY41 2/20 0.61
HDAC6 Q9UBN7 2/20 0.61
HDAC9 Q9UKV0 2/20 0.61
HDAC5 Q9UQL6 2/20 0.61
TNKS O95271 1/20 0.61
HCAR2 Q8TDS4 1/20 0.61
TNKS2 Q9H2K2 1/20 0.61
CYP3A4 P08684 3/20 0.59
PTPN1 P18031 3/20 0.59
RAB9A P51151 2/20 0.58
CYP1B1 Q16678 2/20 0.57
ESR1 P03372 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29966677 1.00 RELA (0.62) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL29462468 1.00 RELA (0.62) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL78426 1.00 RELA (0.62) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL78427 1.00 RELA (0.62) RELAHDAC3HDAC4HDAC1HDAC7
Hydrochloric Acid SCHEMBL6781505 0.98 RELA (0.60) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL7820626 0.94 HDAC3 (0.59) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL7820628 0.94 HDAC3 (0.59) RELAHDAC3HDAC4HDAC1HDAC7
SCHEMBL8746669 0.92 KDM4E (0.64) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL755207 0.92 KDM4E (0.64) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8746632 0.90 KDM4E (0.62) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1171416-B1 3-BICYCLOARYL-2-AMINOMETHYL BICYCLOALKANES AS SEROTONINE REUPTAKE INHIBITORS LILLY CO ELI (GB) 2004-02-18 EP disclosed
US-6384281-B1 USED IN TREATING NERVOUS SYSTEM DISORDERS E.G DEPRESSION, ALCOHOLISM, PAIN, HYPERTENSION, ALZHEIMER'S, MEMORY LOSS, ATTENTION-DEFICIT/OBSESSIVE COMPULSIVE/GASTRIC/CARDIOVASCULAR DISORDERS, PARKINSON'S, ANXIETY, CHRONIC FATIGUE SYNDROME, ELI LILLY AND COMPANY 2002-05-07 US disclosed
EP-1171416-A1 3-BICYCLOARYL-2-AMINOMETHYL BICYCLOALKANES AS SEROTONINE REUPTAKE INHIBITORS ELI LILLY AND COMPANY LIMITED (GB) 2002-01-16 EP disclosed
WO-2000061539-A1 3-BICYCLOARYL-2-AMINOMETHYL BICYCLOALKANES AS SEROTONINE REUPTAKE INHIBITORS ELI LILLY AND COMPANY LIMITED (GB) 2000-10-19 WO disclosed