Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387826 | 0.89 | GAA (0.36) | HSD11B1 | |
| SCHEMBL6551692 | 0.78 | TSHR (0.41) | ALDH1A1NPSR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6552319 | 0.78 | KIF11 (0.45) | MAPK1OPRM1OPRD1OPRK1OPRL1 | |
| Ammonia Solution, Strong SCHEMBL5497679 | 0.70 | — | — | |
| SCHEMBL29213169 | 0.69 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL29390519 | 0.69 | MAPT (0.36) | ALDH1A1TDP1OPRK1 | |
| SCHEMBL7549565 | 0.68 | — | — | |
| SCHEMBL11545311 | 0.67 | LMNA (0.33) | ALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL29506706 | 0.66 | MEN1 (0.59) | ALDH1A1TDP1MAPK1KDM1ARCOR1 | |
| SCHEMBL283196 | 0.66 | MEN1 (0.59) | ALDH1A1TDP1MAPK1KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047411-B1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2004-02-11 | — | — | EP | disclosed |