SCHEMBL6553453

SCHEMBL6553453

O=C(O)c1ccc(COC(=O)c2cccc(CO)c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.63
TSHR P16473 1/20 0.63
KMT2A Q03164 3/20 0.58
TDP1 Q9NUW8 2/20 0.58
SLC6A2 P23975 1/20 0.58
SLC6A3 Q01959 1/20 0.58
RAB9A P51151 8/20 0.56
NPC1 O15118 6/20 0.56
LMNA P02545 3/20 0.54
MAPT P10636 4/20 0.53
TP53 P04637 1/20 0.53
XBP1 P17861 1/20 0.53
HTT P42858 1/20 0.53
HSD17B10 Q99714 1/20 0.53
FOLH1 Q04609 3/20 0.53
PRKCA P17252 1/20 0.52
PRKCD Q05655 1/20 0.52
ALDH1A1 P00352 4/20 0.51
HPGD P15428 2/20 0.51
KDM4E B2RXH2 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15012759 0.91 TDP1 (0.71) SMN1; SMN2TSHRKMT2ATDP1SLC6A2
SCHEMBL181934 0.83 TDP1 (0.73) SMN1; SMN2KMT2ATDP1SLC6A2SLC6A3
SCHEMBL6274205 0.82 KMT2A (0.79) SMN1; SMN2KMT2ATDP1SLC6A2SLC6A3
SCHEMBL6001726 0.82 KMT2A (0.58) SMN1; SMN2TSHRKMT2ATDP1SLC6A2
SCHEMBL6530665 0.82 RAB9A (0.56) SMN1; SMN2TSHRKMT2ATDP1SLC6A2
SCHEMBL1482628 0.81 KMT2A (0.76) SMN1; SMN2TSHRKMT2ATDP1SLC6A2
SCHEMBL419555 0.81 KMT2A (0.81) SMN1; SMN2KMT2ATDP1SLC6A2SLC6A3
Benzyl Benzoate SCHEMBL8359694 0.81 KMT2A (0.89) SMN1; SMN2TSHRKMT2ATDP1SLC6A2
SCHEMBL312910 0.81 TDP1 (0.81) SMN1; SMN2KMT2ATDP1SLC6A2SLC6A3
SCHEMBL11777793 0.81 KMT2A (0.74) SMN1; SMN2TSHRKMT2ATDP1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1485470-A2 USE OF XYLENE MONOOXYGENASE FOR THE OXIDATION OF SUBSTITUTED MONOCYCLIC AROMATIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-12-15 EP disclosed
US-20030073206-A1 Use of xylene monooxygenase for the oxidation of substituted monocyclic aromatic compounds E. I. DU PONT DE NEMOURS AND COMPANY 2003-04-17 US disclosed
WO-2003014368-A2 USE OF XYLENE MONOOXYGENASE FOR THE OXIDATION OF SUBSTITUTED MONOCYCLIC AROMATIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-20 WO disclosed