Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.55 |
| ▸ | TNKS | O95271 | 2/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GPR3 | P46089 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405478 | 0.84 | PARP1 (0.54) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL861749 | 0.74 | PARP1 (0.59) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL20227575 | 0.72 | SIRT1 (0.47) | PARP1KDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL6555513 | 0.72 | PARP1 (0.59) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL29204435 | 0.72 | PARP1 (0.64) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL20227724 | 0.71 | CTSV (0.51) | PARP1KDM4EALDH1A1HSD17B10BRD4 | |
| SCHEMBL12795339 | 0.71 | KDM4E (0.55) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL6555511 | 0.71 | PARP1 (0.54) | PARP1KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL7028562 | 0.71 | CA12 (0.47) | PARP1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL2215587 | 0.70 | AHR (0.48) | PARP1KDM4EMEN1ALDH1A1GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |