SCHEMBL6554383

SCHEMBL6554383

Cc1ccc(N(CCN(C)C)S(=O)(=O)c2ccccc2)c(OCCCCNC(=O)OC(C)(C)C)c1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.45
CA2 P00918 6/20 0.45
CA12 O43570 5/20 0.45
CA9 Q16790 5/20 0.45
PPARA Q07869 1/20 0.43
APOBEC3A P31941 1/20 0.40
APOBEC3G Q9HC16 1/20 0.40
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
KEAP1 Q14145 4/20 0.39
NFE2L2 Q16236 4/20 0.39
ALDH1A1 P00352 1/20 0.38
CCNC P24863 1/20 0.38
CDK8 P49336 1/20 0.38
CKS1B P61024 1/20 0.37
SKP1 P63208 1/20 0.37
SKP2 Q13309 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7501177 0.89 CA1 (0.48) CA1CA2CA12CA9PPARA
Hydrochloric Acid SCHEMBL8368789 0.85 APOBEC3A (0.41) PPARAAPOBEC3AAPOBEC3GMAPTTSHR
SCHEMBL6554463 0.78 PPARA (0.52) CA1CA2CA12CA9PPARA
SCHEMBL9185207 0.74 LMNA (0.50) CA1CA2CA12CA9MAPT
SCHEMBL7451126 0.73 MEN1 (0.43) PPARAAPOBEC3AAPOBEC3GMAPTKEAP1
SCHEMBL7969119 0.72 CA12 (0.53) CA1CA2CA12CA9PPARA
SCHEMBL8698623 0.72 CA1 (0.54) CA1CA2CA12CA9PPARA
SCHEMBL21708240 0.71 KEAP1 (0.53) CA1CA2CA12CA9APOBEC3A
SCHEMBL7427859 0.71 GPBAR1 (0.38) CA1CA2CA12CA9ALDH1A1
SCHEMBL4278756 0.70 CA12 (0.51) CA1CA2CA12CA9PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0883405-B1 AMIDINO PROTEASE INHIBITORS DIMENSIONAL PHARM INC (US) 2004-02-25 EP disclosed
US-6414020-B2 ANTIPROTEOLYTIC AMIDINO OR DERIVATIVE USEFUL FOR TREATING PENCREATITIS, THROMBOSIS, ISCHEMIA, STROKE, RESTENOSIS, EMPHYSEMA OR INFLAMMATION 3- DIMENSIONAL PHARMACEUTICALS, INC. 2002-07-02 US disclosed
US-6281206-B1 AMIDINO AND BENZAMIDINO COMPOUNDS 3-DIMENSIONAL PHARMACEUTICALS, INC. 2001-08-28 US disclosed
US-6225302-B1 Amidino protease inhibitors 3-DIMENSIONAL PHARMACEUTICALS, INC. 2001-05-01 US disclosed
US-6133315-A ADMINISTERING TO TREAT PANCREATITIS, THROMBOSIS, ISCHEMIA, STROKE, RESTENOSIS, EMPHYSEMA OR INFLAMMATION IN A MAMMAL; COMPOUNDS SUCH AS 2-CHLOROBENZENESULFONIC ACID 3-(3-AMIDINOPROPOXY)-5-METHYLPHENYL ESTER HYDROCHLORIDE 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-10-17 US disclosed
US-6034127-A CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-03-07 US disclosed
EP-0883405-A4 AMIDINO PROTEASE INHIBITORS DIMENSIONAL PHARM INC (US) 1999-04-28 EP disclosed
EP-0883405-A1 AMIDINO PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1998-12-16 EP disclosed
WO-1997024135-A1 AMIDINO PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1997-07-10 WO disclosed