Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | BMP1 | P13497 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186002 | 0.82 | ESR1 (0.50) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL9186195 | 0.80 | ESR1 (0.48) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL9188513 | 0.80 | ESR1 (0.57) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL5704478 | 0.79 | PSEN1 (0.44) | LMNAKEAP1NFE2L2MAPTCA12 | |
| SCHEMBL9189756 | 0.78 | ESR1 (0.54) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL9186869 | 0.77 | ALOX5 (0.53) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL14502622 | 0.77 | KEAP1 (0.66) | LMNAGAAHTTKEAP1NFE2L2 | |
| SCHEMBL9100684 | 0.76 | CKS1B (0.52) | GAAMAPTCA12CA1CA2 | |
| SCHEMBL8466425 | 0.74 | ESR1 (0.76) | KEAP1NFE2L2ESR1CA12CA9 | |
| SCHEMBL6554383 | 0.74 | CA1 (0.45) | GAAKEAP1NFE2L2MAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497202-B1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5217964-A | POLYAMINE THIOLS AS RADIOPROTECTIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0497202-A1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-05 | — | — | EP | disclosed |