Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742045 | 1.00 | ALDH1A1 (0.42) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL6554592 | 0.92 | ALDH1A1 (0.37) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL6553263 | 0.92 | ALDH1A1 (0.37) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL6554596 | 0.92 | ALDH1A1 (0.37) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL6553260 | 0.92 | ALDH1A1 (0.37) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL14542891 | 0.91 | ALDH1A1 (0.34) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL7569244 | 0.91 | ALDH1A1 (0.34) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL7569240 | 0.91 | ALDH1A1 (0.34) | ALDH1A1PKMHTTKDM4ELMNA | |
| SCHEMBL6554805 | 0.82 | LMNA (0.31) | ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL6554823 | 0.82 | LMNA (0.31) | ALDH1A1PKMHTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000950-B1 | Novel indanylidene compounds | HOFFMANN LA ROCHE (CH) | 2004-02-25 | — | — | EP | disclosed |
| US-6416746-B1 | ULTRAVIOLET RAY AND LIGHT SCREENING MATERIAL GRAFTED TO SILANE, OLIGOSILOXANE, OR POLYSILOXANE WITH IMPROVED SOLUBILITY AND LITTLE PENETRATION; FOR USE IN COSMETICS | ROCHE VITAMINS INC. | 2002-07-09 | — | — | US | disclosed |
| JP-2000143608-A | NOVEL INDANYLIDENE COMPOUND | F HOFFMANN LA ROCHE AG | 2000-05-26 | — | — | JP | disclosed |
| EP-1000950-A2 | Novel indanylidene compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-17 | — | — | EP | disclosed |