Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554293 | 0.83 | HTT (0.54) | KMT2AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1633723 | 0.83 | HTR2A (0.42) | HTR2AHTR2CHTR2BPIN1KMT2A | |
| SCHEMBL27687662 | 0.81 | HTT (0.42) | PIN1KMT2AHTTALDH1A1 | |
| SCHEMBL4826643 | 0.76 | ALDH1A1 (0.41) | KMT2AAKR1B1KDM4EALDH1A1MAPK1 | |
| SCHEMBL1262117 | 0.73 | HDAC4 (0.35) | KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL6554195 | 0.72 | NR3C1 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL5643865 | 0.71 | P2RX7 (0.43) | AKR1B1ALDH1A1 | |
| SCHEMBL4816885 | 0.71 | NR3C1 (0.40) | HTR2AHTR2CHTR2BPIN1 | |
| SCHEMBL30040332 | 0.71 | HTT (0.67) | KMT2AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1634501 | 0.70 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2BPIN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133486-B1 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AG (DE) | 2004-12-22 | — | — | EP | disclosed |
| US-6323199-B1 | AROMATIC HETEROCYCLIC HYDROXY AMINES OR AMIDES FOR TREATMENT OF INFLAMMATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-11-27 | — | — | US | disclosed |
| EP-1133486-A2 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032584-A2 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |