SCHEMBL6555768

SCHEMBL6555768

COC(c1cc(-c2ccc(C(=O)O)cc2)cc2cc3c(cc12)C(C)(C)CCC3(C)C)C(F)(F)F

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
RARB P10826 12/20 0.55
RARG P13631 12/20 0.55
RARA P10276 10/20 0.55
RXRA P19793 12/20 0.44
HNF4A P41235 2/20 0.44
RXRB P28702 4/20 0.44
RXRG P48443 4/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9119993 0.88 RARA (0.46) RARBRARGRARARXRAHNF4A
SCHEMBL9051345 0.82 RARB (0.63) RARBRARGRARARXRARXRB
SCHEMBL9118198 0.78 RARB (0.60) RARBRARGRARARXRAHNF4A
SCHEMBL9049859 0.77 RARB (0.66) RARBRARGRARARXRARXRB
SCHEMBL9050626 0.77 RARB (0.69) RARBRARGRARARXRARXRB
SCHEMBL9054209 0.77 RARG (0.69) RARBRARGRARARXRARXRB
SCHEMBL9049761 0.77 RARB (0.69) RARBRARGRARARXRARXRB
SCHEMBL4192048 0.76 RARB (0.67) RARBRARGRARARXRARXRB
SCHEMBL9050596 0.75 RARB (0.47) RARBRARGRARARXRAHNF4A
SCHEMBL9048881 0.74 RARB (0.66) RARBRARGRARARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874626-B1 USE OF INHIBITORS OF RETINOIC ACID ACTIVITY FOR WOUND HEALING CT INTERNAT DERECH S DERMATOLO (FR) 2004-12-29 EP claimed
EP-0892633-B1 USE OF INHIBITORS OF THE ACTIVITY OF RETINOIC ACID FOR TREATING SENSITIVE SKIN AND/OR ACUTE DAMAGE INDUCED BY UV RADIATION GALDERMA RECH DERMATOLOGIQUE (FR) 2003-03-05 EP claimed
US-6248749-B1 TOPICALLY APPLYING RETINOID ANTAGONIST TO SENSITIVE SKIN TO TREAT ALLERGIES/SUNBURN CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-06-19 US claimed
US-5973007-A SURGERY, TRAUMA WOUNDS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1999-10-26 US claimed
US-20020137794-A1 Retinoic acid receptor (RAR) agonists, agonists for steroid/thyroid hormone receptor superfamily, and an agonist for a heterodimer partner SALK INSTITUTE FOR BIOLOGICAL STUDIES, THE 2002-09-26 US disclosed
US-6436993-B1 SYNERGISTIC MIXTURES OF RETINOIC ACID RECEPTOR (RAR) ANTAGONISTS AND STEROID, THYROID OR RETINOID RECEPTOR AGONISTS SUCH AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS USED TO CONTROL CELLULAR PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2002-08-20 US disclosed
US-6248749-B1 TOPICALLY APPLYING RETINOID ANTAGONIST TO SENSITIVE SKIN TO TREAT ALLERGIES/SUNBURN CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-06-19 US disclosed
WO-2001003659-A1 USE OF RAR ANTAGONISTS AS MODULATORS OF HORMONE MEDIATED PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2001-01-18 WO disclosed
US-5973007-A SURGERY, TRAUMA WOUNDS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1999-10-26 US disclosed
WO-1995033745-A9 NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY 1996-01-18 WO disclosed
WO-1995033745-A2 NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY SRI INTERNATIONAL (US) 1995-12-14 WO disclosed