Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 11/20 | 0.38 |
| ▸ | CMA1 | P23946 | 9/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556548 | 0.84 | ELANE (0.61) | ELANEIL1RNERAP2ERAP1CTRC | |
| SCHEMBL6556228 | 0.84 | ELANE (0.54) | ELANECTRCCMA1 | |
| SCHEMBL6556270 | 0.81 | CTRC (0.62) | CTRCCMA1 | |
| SCHEMBL6556254 | 0.80 | CTRB1 (0.41) | — | |
| SCHEMBL6556285 | 0.79 | ALDH1A1 (0.44) | — | |
| SCHEMBL6556287 | 0.76 | ELANE (0.51) | ELANECTRC | |
| SCHEMBL6556188 | 0.76 | ELANE (0.63) | ELANECTRC | |
| SCHEMBL6558119 | 0.74 | ELANE (0.65) | ELANECTRCCMA1 | |
| SCHEMBL7292398 | 0.73 | ELANE (0.51) | ELANEIL1RNERAP2ERAP1CTRC | |
| SCHEMBL7292100 | 0.73 | ELANE (0.65) | ELANEIL1RNERAP2ERAP1CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0826671-A1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | THE GREEN CROSS CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |