Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368282 | 0.83 | PARP1 (0.58) | PARP1KDM4EMTNR1ALMNASLC6A2 | |
| SCHEMBL3261062 | 0.83 | PARP1 (0.54) | PARP1KDM4EMTNR1ALMNASLC6A2 | |
| SCHEMBL18196600 | 0.79 | HPGD (0.42) | HPGDKDM4EHSD17B10MTNR1ALMNA | |
| SCHEMBL5785526 | 0.79 | PARP1 (0.47) | PARP1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL5200399 | 0.75 | MTNR1A (0.47) | HPGDKDM4EHSD17B10MTNR1AMAPT | |
| SCHEMBL1065556 | 0.75 | PARP1 (0.66) | PARP1KDM4EHSD17B10LMNAALDH1A1 | |
| Bicarbonate SCHEMBL9415505 | 0.73 | CTNNB1 (0.44) | PARP1HPGDKDM4EHSD17B10MTNR1A | |
| SCHEMBL6805074 | 0.72 | ACACB (0.37) | HPGDKDM4EHSD17B10MTNR1ALMNA | |
| SCHEMBL6934190 | 0.72 | KDM4E (0.35) | HPGDKDM4EHSD17B10MTNR1ALMNA | |
| SCHEMBL28330085 | 0.72 | PARP1 (0.49) | PARP1KDM4EMTNR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133486-B1 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AG (DE) | 2004-12-22 | — | — | EP | disclosed |
| EP-1133486-A2 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032584-A2 | NONSTEROIDAL ANTIINFLAMMATORIES | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |