SCHEMBL6556263

SCHEMBL6556263

NC(=O)C(=O)c1ncccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.50
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
CTNNB1 P35222 1/20 0.38
WNT3A P56704 1/20 0.38
PARP1 P09874 2/20 0.36
NAPRT Q6XQN6 2/20 0.35
HSP90AA1 P07900 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.34
P4HTM Q9NXG6 1/20 0.34
KDM4E B2RXH2 3/20 0.33
MKNK1 Q9BUB5 2/20 0.33
MKNK2 Q9HBH9 2/20 0.33
ALDH1A1 P00352 2/20 0.33
TSHR P16473 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
MC4R P32245 1/20 0.33
ADRA1A P35348 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5086411 0.83 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
SCHEMBL158178 0.78
Hydrochloric Acid SCHEMBL27440453 0.76 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
SCHEMBL27431959 0.76 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
Bromide SCHEMBL10718877 0.76 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
Hydrochloric Acid SCHEMBL25337662 0.76 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
Ammonia Solution, Strong SCHEMBL17104818 0.76 P2RX7 (0.52) P2RX7CES2CES1CTNNB1WNT3A
SCHEMBL726451 0.76 P2RX7 (0.46) P2RX7CES2CES1CTNNB1WNT3A
SCHEMBL31589963 0.75 P2RX7 (0.46) P2RX7CES2CES1CTNNB1WNT3A
Urea SCHEMBL28123603 0.72 P2RX7 (0.48) P2RX7CTNNB1WNT3APARP1NAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0826671-B1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME MITSUBISHI PHARMA CORP (JP) 2004-12-29 EP disclosed
US-6080738-A USEFUL AS CHYMASE INHIBITORS AND CAN BE USED FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II YOSHITOMI PHARMACEUTICALS INDUSTRIES, LTD. (JP) 2000-06-27 US disclosed
EP-0940400-A1 NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-09-08 EP disclosed
US-5948785-A USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. THE GREEN CROSS CORPORATION (JP) 1999-09-07 US disclosed
EP-0826671-A1 HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME THE GREEN CROSS CORPORATION (JP) 1998-03-04 EP disclosed