Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380709 | 0.81 | ALDH1A1 (0.57) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL30054040 | 0.80 | MAPT (0.68) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL6556764 | 0.80 | MAPT (0.68) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL6556773 | 0.77 | MAPT (0.62) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL30839701 | 0.77 | ALDH1A1 (0.45) | MAPTMAPK1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6556733 | 0.76 | GAA (0.43) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL6556887 | 0.76 | MAPT (0.61) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL6557168 | 0.75 | ALDH1A1 (0.47) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL6556822 | 0.74 | MAPT (0.41) | MAPTCYP1A2CYP3A4TSHRMAPK1 | |
| SCHEMBL18157812 | 0.74 | RORC (0.41) | MAPTCYP1A2CYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | claimed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |