Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.62 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493872 | 1.00 | CHRNA7 (0.62) | CHRNA7FAAHTP53LMNAHTT | |
| SCHEMBL5168559 | 1.00 | CHRNA7 (0.62) | CHRNA7FAAHTP53LMNAHTT | |
| Hydrochloric Acid SCHEMBL5168177 | 0.98 | CHRNA7 (0.60) | CHRNA7FAAHTP53LMNAHTT | |
| SCHEMBL9967269 | 0.85 | ALDH1A1 (0.62) | FAAHHTTRAB9AALDH1A1 | |
| SCHEMBL9967270 | 0.82 | RAB9A (0.59) | CHRNA7LMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1459729 | 0.81 | PTPN1 (0.54) | FAAHLMNAHTTSMN1; SMN2RAB9A | |
| SCHEMBL9967272 | 0.81 | RAB9A (0.45) | CHRNA7LMNASMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL6554324 | 0.80 | PTPN1 (0.53) | FAAHLMNARAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL2492465 | 0.80 | RAB9A (0.44) | CHRNA7LMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10007116 | 0.80 | LMNA (0.51) | CHRNA7LMNAHTTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487834-B1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | BAYER HEALTHCARE AG (DE) | 2007-04-25 | — | — | EP | disclosed |
| EP-1487834-A1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | Bayer Aktiengesellschaft (DE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078431-A1 | AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | BAYER HEALTHCARE AG (DE) | 2003-09-25 | — | — | WO | disclosed |