Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557047 | 0.82 | SLC2A1 (0.46) | CYP2D6HTTSLC2A1SLC6A4TSHR | |
| SCHEMBL6558728 | 0.80 | ALDH1A1 (0.43) | HTTSLC2A1TSHRCYP1A2CYP3A4 | |
| SCHEMBL6558698 | 0.77 | SLC2A1 (0.41) | HTTSLC2A1SLC6A4TSHRCYP1A2 | |
| SCHEMBL8053600 | 0.77 | SLC2A1 (0.41) | HTTSLC2A1TSHRCYP1A2CYP3A4 | |
| SCHEMBL6556784 | 0.77 | ALDH1A1 (0.47) | HTTHSD11B1SLC2A1SLC6A4HTR2A | |
| SCHEMBL11231431 | 0.76 | CYP2D6 (0.50) | CYP2D6HTTCYP1A2CYP3A4MAPT | |
| SCHEMBL6557998 | 0.76 | SLC2A1 (0.46) | HTTSLC2A1SLC6A4TSHRCYP1A2 | |
| SCHEMBL22278541 | 0.74 | SLC2A1 (0.49) | SLC2A1KCNH2TSHRCYP1A2CYP3A4 | |
| SCHEMBL6556691 | 0.73 | SLC2A1 (0.43) | HTTSLC2A1SLC6A4TSHRCYP1A2 | |
| SCHEMBL22930904 | 0.73 | PDE2A (0.54) | PDE2AHSD11B1KCNH2SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | claimed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |