Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557166 | 0.92 | SYK (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL6557163 | 0.92 | SYK (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL9312434 | 0.83 | SYK (0.54) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL8989433 | 0.82 | HTR6 (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| Hydrochloric Acid SCHEMBL9876688 | 0.80 | HTR6 (0.53) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL21460235 | 0.80 | ALDH1A1 (0.49) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL21460320 | 0.77 | HTR6 (0.46) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL21460303 | 0.76 | KCNH2 (0.43) | SYKKCNH2MAPK3MAPK1AURKB | |
| SCHEMBL2343007 | 0.76 | KDM1A (0.51) | HTR6CHEK2 | |
| SCHEMBL17961734 | 0.76 | KDM1A (0.51) | HTR6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |