SCHEMBL6557230

SCHEMBL6557230

COC(=O)NCc1cc(C#C[Si](C)(C)C)ccc1F

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.39
ROCK2 O75116 3/20 0.37
ROCK1 Q13464 3/20 0.37
TSHR P16473 1/20 0.37
KMT2A Q03164 1/20 0.36
HTT P42858 1/20 0.36
GABRA1 P14867 2/20 0.35
GABRG2 P18507 2/20 0.35
GABRB3 P28472 2/20 0.35
GABRA5 P31644 2/20 0.35
GABRA3 P34903 2/20 0.35
GABRA2 P47869 2/20 0.35
GABRA4 P48169 2/20 0.35
GABRA6 Q16445 1/20 0.35
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1476698 0.89 GABRA1 (0.42) SMN1; SMN2TSHRHTTGABRA1GABRG2
SCHEMBL1476738 0.88 GABRA1 (0.41) HTTGABRA1GABRG2GABRB3GABRA5
SCHEMBL1477497 0.87 SETDB1 (0.43) HTTALDH1A1LMNA
SCHEMBL3837338 0.87 ALDH1A1 (0.38) TSHRKMT2AHTTGABRA1GABRG2
SCHEMBL752442 0.86 TSHR (0.47) SMN1; SMN2ROCK2ROCK1TSHRKMT2A
SCHEMBL6557549 0.82 HTT (0.46) SMN1; SMN2ROCK2ROCK1TSHRKMT2A
SCHEMBL6557413 0.81 EGFR (0.37) SMN1; SMN2ROCK2ROCK1TSHRKMT2A
SCHEMBL6557520 0.80 TSHR (0.38) SMN1; SMN2ROCK2ROCK1TSHRKMT2A
SCHEMBL15729791 0.78 GABRA1 (0.41) HTTGABRA1GABRG2GABRB3GABRA5
SCHEMBL1476652 0.77 IKBKB (0.37) KMT2AGABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1085010-B1 PHENYLACETYLENE DERIVATIVES AND AGRICULTURAL/HORTICULTURAL BACTERICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2004-03-10 EP disclosed
US-6313071-B1 Phenylacetylene derivatives and agricultural/horticultural fungicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2001-11-06 US disclosed
EP-1085010-A1 PHENYLACETYLENE DERIVATIVES AND AGRICULTURAL/HORTICULTURAL BACTERICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2001-03-21 EP disclosed