Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8917342 | 0.89 | HTR2A (0.36) | HTR2APDE10A | |
| Hydrochloric Acid SCHEMBL8917252 | 0.86 | HTR2A (0.42) | HTR2APDE10ACA1CA2 | |
| SCHEMBL3981626 | 0.84 | HTR2A (0.44) | HTR2APDE10ACA1CA2 | |
| Hydrochloric Acid SCHEMBL7251524 | 0.83 | MYC (0.38) | HTR2ACA1CA2 | |
| SCHEMBL27335604 | 0.78 | HTR2A (0.44) | HTR2APDE10ACA1CA2 | |
| Hydrochloric Acid SCHEMBL5366067 | 0.78 | HTR2A (0.40) | HTR2ACA1CA2 | |
| Hydrochloric Acid SCHEMBL5352654 | 0.78 | HTR2A (0.47) | HTR2APDE10ACA1CA2 | |
| SCHEMBL8857191 | 0.77 | HTR2A (0.42) | HTR2ACA1CA2 | |
| SCHEMBL7605035 | 0.77 | HTR2A (0.37) | HTR2APDE10ACA1CA2 | |
| Hydrochloric Acid SCHEMBL8916641 | 0.77 | MEN1 (0.34) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705851-B9 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-0705851-B1 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-01-21 | — | — | EP | disclosed |
| US-5710224-A | CATALYTIC POLYMERIZATION OF ETHYLENE USING FLUORENE INDENYL ETHANE ZIRCONIUM DICHLORIDE WITH METALLOCENE | PHILLIPS PETROLEUM COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0729978-A1 | Polyethylene and method for production thereof | PHILLIPS PETROLEUM COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5534473-A | METALLOCENES AND COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0705851-A2 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |