Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HEXA | P06865 | 1/20 | 0.31 |
| ▸ | HEXB | P07686 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8917342 | 0.91 | HTR2A (0.36) | HTR2APDE10ATNKS2PBRM1MYC | |
| Hydrochloric Acid SCHEMBL8916641 | 0.90 | MEN1 (0.34) | HTR2AMEN1ALDH1A1KMT2AHTR2C | |
| Hydrochloric Acid SCHEMBL6557592 | 0.86 | HTR2A (0.36) | HTR2APDE10ACA1CA2 | |
| Hydrochloric Acid SCHEMBL5352654 | 0.85 | HTR2A (0.47) | HTR2APDE10ACA1CA2BCHE | |
| SCHEMBL27335604 | 0.82 | HTR2A (0.44) | HTR2APDE10ACA1CA2TNKS2 | |
| Hydrochloric Acid SCHEMBL7251524 | 0.80 | MYC (0.38) | HTR2ACA1CA2TNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL8917790 | 0.79 | PDE10A (0.39) | HTR2APDE10A | |
| Hydrochloric Acid SCHEMBL8174122 | 0.77 | HTR2A (0.54) | HTR2APDE10ACA1CA2BCHE | |
| SCHEMBL633764 | 0.77 | HTR2A (0.58) | HTR2APDE10ACA1CA2BCHE | |
| Hydrochloric Acid SCHEMBL8918026 | 0.76 | PDE10A (0.36) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |