SCHEMBL9804244

SCHEMBL9804244

Fc1cc(Br)cc(F)c1OC(F)(F)Cl

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.34
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28819149 0.82 MAPT (0.36) MAPTNOTUM
SCHEMBL6558034 0.82 MAPT (0.36) MAPTNOTUM
SCHEMBL9013332 0.80 MAPT (0.35) MAPTNOTUM
SCHEMBL7767195 0.78 MAPT (0.41) MAPTNOTUM
SCHEMBL6684061 0.74 MAPT (0.35) MAPT
SCHEMBL7765300 0.74 MAPK1 (0.38)
SCHEMBL9008495 0.72 MAPT (0.31) MAPT
SCHEMBL7797155 0.72 ALDH1A1 (0.37) MAPT
SCHEMBL10986 0.72 CA2 (0.41) MAPT
SCHEMBL930657 0.70 KDM4E (0.40) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104761437-A Preparation method of 4-bromo-2, 6-difluorotrifluoromethoxybenzene SHANGHAI CHEMSPEC INTERNAT LTD 2015-07-08 CN disclosed
EP-0240121-B1 DIPHENYL ETHER DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-17 EP disclosed
EP-0390228-A2 Chemical intermediates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-10-03 EP disclosed
US-4791139-A Diphenyl ether derivatives and their use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-12-13 US disclosed
EP-0240121-A2 Diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-07 EP disclosed