Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560089 | 0.91 | DRD2 (0.49) | DRD2DRD4DRD3OPRM1OPRD1 | |
| SCHEMBL4512261 | 0.81 | RIPK1 (0.50) | DRD2OPRM1OPRD1OPRK1RIPK1 | |
| SCHEMBL4495242 | 0.79 | RIPK1 (0.49) | DRD2OPRM1OPRD1OPRK1RIPK1 | |
| SCHEMBL27400144 | 0.74 | NPY1R (0.48) | OPRM1OPRD1OPRK1RIPK1QPCT | |
| SCHEMBL6558776 | 0.73 | DRD2 (0.54) | DRD2DRD4DRD3OPRM1OPRD1 | |
| SCHEMBL18384865 | 0.71 | RIPK1 (0.55) | RIPK1NPC1RAB9AMEN1GAA | |
| SCHEMBL7393183 | 0.71 | DRD2 (0.61) | DRD2DRD4DRD3KCNH2RAB9A | |
| SCHEMBL13730744 | 0.70 | DRD2 (1.00) | DRD2DRD4DRD3KCNH2NPC1 | |
| SCHEMBL6560943 | 0.69 | DRD2 (0.47) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL25932464 | 0.69 | RIPK1 (0.39) | DRD2OPRM1OPRD1OPRK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |