Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559415 | 0.93 | DRD2 (0.43) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL6558776 | 0.82 | DRD2 (0.54) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL6558758 | 0.74 | DRD2 (0.49) | DRD2DRD4DRD3 | |
| SCHEMBL6561211 | 0.72 | DRD2 (0.44) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL6558739 | 0.69 | DRD2 (0.54) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL6560926 | 0.66 | DRD2 (0.41) | DRD2DRD4DRD3 | |
| SCHEMBL7090398 | 0.66 | GAA (0.61) | NPC1RAB9ARAD52KMT2AMEN1 | |
| SCHEMBL7393183 | 0.66 | DRD2 (0.61) | DRD2DRD4DRD3RAB9A | |
| SCHEMBL16975325 | 0.63 | ALDH1A1 (0.52) | NPC1RAB9ARAD52KMT2AMEN1 | |
| SCHEMBL6560089 | 0.63 | DRD2 (0.49) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |