Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560799 | 0.91 | HTR2B (0.42) | TRPV1KCNA5SIRT2HTR2BHTR1A | |
| SCHEMBL6558641 | 0.83 | TRPV1 (0.39) | TRPV1KCNA5SIRT2HTR2BHTR1A | |
| SCHEMBL6559589 | 0.82 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL6560806 | 0.82 | KCNA5 (0.44) | TRPV1KCNA5SIRT2CTSDBACE1 | |
| SCHEMBL6559382 | 0.80 | MAPT (0.45) | TRPV1KCNA5SIRT2HTR2BHTR1A | |
| SCHEMBL6559509 | 0.80 | TRPV1 (0.45) | TRPV1KCNA5 | |
| SCHEMBL6560445 | 0.79 | KCNA5 (0.44) | TRPV1KCNA5SIRT2CTSDBACE1 | |
| SCHEMBL6560790 | 0.79 | SIRT2 (0.44) | TRPV1KCNA5SIRT2 | |
| SCHEMBL6559918 | 0.78 | TRPV1 (0.38) | TRPV1KCNA5SIRT2CTSDBACE1 | |
| SCHEMBL6560820 | 0.78 | KCNA5 (0.36) | TRPV1KCNA5SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |