Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | TLR3 | O15455 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558641 | 0.83 | TRPV1 (0.39) | SIRT2TRPV1KCNA5HTT | |
| SCHEMBL6559479 | 0.83 | ALDH1A1 (0.35) | SIRT2TLR3MAPTSMN1; SMN2LMNA | |
| SCHEMBL6559589 | 0.82 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL6560806 | 0.82 | KCNA5 (0.44) | SIRT2TRPV1KCNA5 | |
| SCHEMBL6559382 | 0.80 | MAPT (0.45) | SIRT2TRPV1KCNA5MAPTSMN1; SMN2 | |
| SCHEMBL6559509 | 0.80 | TRPV1 (0.45) | TRPV1KCNA5LMNAALDH1A1KMT2A | |
| SCHEMBL6560445 | 0.79 | KCNA5 (0.44) | SIRT2TRPV1KCNA5MEN1KMT2A | |
| SCHEMBL6559192 | 0.79 | TRPV1 (0.37) | SIRT2TRPV1KCNA5 | |
| SCHEMBL6560799 | 0.79 | HTR2B (0.42) | SIRT2TRPV1KCNA5MAPTHTT | |
| SCHEMBL6559918 | 0.78 | TRPV1 (0.38) | SIRT2TRPV1KCNA5MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204134-C | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 2005-06-01 | — | — | CN | disclosed |
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| CN-1169429-A | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 1998-01-07 | — | — | CN | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |