Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559192 | 0.91 | TRPV1 (0.37) | HTR2BTMEM97SIGMAR1HTR1ATRPV1 | |
| SCHEMBL6559509 | 0.85 | TRPV1 (0.45) | TRPV1KCNA5ALDH1A1PFKFB3 | |
| SCHEMBL6558641 | 0.83 | TRPV1 (0.39) | HTR2BSIGMAR1HTR1ATRPV1CTSD | |
| SCHEMBL6559589 | 0.82 | TRPV1 (0.52) | TRPV1CYP3A4 | |
| SCHEMBL6560806 | 0.82 | KCNA5 (0.44) | TRPV1CTSDBACE1BACE2KCNA5 | |
| SCHEMBL6560445 | 0.81 | KCNA5 (0.44) | TRPV1CTSDBACE1BACE2KCNA5 | |
| SCHEMBL6602406 | 0.81 | KCNE1 (0.52) | HTR2BTMEM97SIGMAR1CTSDBACE1 | |
| SCHEMBL6560790 | 0.79 | SIRT2 (0.44) | TRPV1KCNA5SIRT2ALDH1A1MAPT | |
| SCHEMBL6560820 | 0.78 | KCNA5 (0.36) | TRPV1KCNA5SIRT2CYP2D6 | |
| SCHEMBL6559931 | 0.77 | KCNA5 (0.44) | TRPV1CTSDBACE1KCNA5SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204134-C | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 2005-06-01 | — | — | CN | disclosed |
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| CN-1169429-A | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 1998-01-07 | — | — | CN | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |