Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.37 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559382 | 0.88 | MAPT (0.45) | TRPV1SIRT2CTSDBACE1KCNE1 | |
| SCHEMBL6558641 | 0.82 | TRPV1 (0.39) | TRPV1SIRT2CTSDBACE1HTT | |
| SCHEMBL6602406 | 0.82 | KCNE1 (0.52) | CTSDBACE1KCNE1KCNQ1MAPT | |
| SCHEMBL6559589 | 0.81 | TRPV1 (0.52) | TRPV1KCNE1KCNQ1 | |
| SCHEMBL6560806 | 0.81 | KCNA5 (0.44) | TRPV1SIRT2CTSDBACE1KCNA5 | |
| SCHEMBL6559231 | 0.80 | KCNE1 (0.52) | TRPV1SIRT2CTSDBACE1KCNE1 | |
| SCHEMBL6560829 | 0.79 | MAPT (0.41) | TRPV1MAPTALDH1A1HTTTAAR1 | |
| SCHEMBL6559509 | 0.79 | TRPV1 (0.45) | TRPV1KCNE1KCNQ1ALDH1A1KCNA5 | |
| SCHEMBL6559931 | 0.79 | KCNA5 (0.44) | TRPV1SIRT2CTSDBACE1MAPT | |
| SCHEMBL7464900 | 0.79 | KCNE1 (0.52) | TRPV1SIRT2CTSDBACE1KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204134-C | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 2005-06-01 | — | — | CN | disclosed |
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| CN-1169429-A | Sulfamine-substituted benzodihydopyran, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST AG (DE) | 1998-01-07 | — | — | CN | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |