Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559952 | 0.92 | KCNA5 (0.41) | SMN1; SMN2TSHRCYP1A2CYP2C19MEN1 | |
| SCHEMBL6558710 | 0.91 | KCNA5 (0.35) | SMN1; SMN2TSHRCYP1A2CYP2C19MEN1 | |
| SCHEMBL6560813 | 0.89 | KCNE1 (0.42) | SMN1; SMN2TSHRCYP1A2CYP2C19MEN1 | |
| SCHEMBL6559500 | 0.88 | NPSR1 (0.38) | SMN1; SMN2CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL6559403 | 0.88 | KCNA5 (0.37) | SMN1; SMN2TSHRMEN1KMT2ARAB9A | |
| SCHEMBL7830067 | 0.87 | KCNE1 (0.37) | SMN1; SMN2TSHRMEN1KMT2ARAB9A | |
| SCHEMBL6559604 | 0.87 | MEN1 (0.36) | SMN1; SMN2TSHRCYP1A2CYP2C19MEN1 | |
| SCHEMBL6559333 | 0.85 | KCNE1 (0.44) | CYP1A2CYP2C19MEN1KMT2ACNR2 | |
| SCHEMBL6559277 | 0.83 | KCNE1 (0.40) | SMN1; SMN2TSHRMEN1KMT2ARAB9A | |
| SCHEMBL6559569 | 0.82 | RAB9A (0.37) | SMN1; SMN2TSHRMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |