Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 9/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593237 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL6559505 | 0.89 | KDM4E (0.61) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL6559504 | 0.89 | KDM4E (0.61) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL8649206 | 0.85 | MAOB (0.43) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL6593248 | 0.85 | MAOB (0.43) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL619822 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL619821 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL10609191 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL10609186 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 | |
| SCHEMBL17027046 | 0.81 | KDM4E (0.44) | ALDH1A1KDM4EMAPTTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |