Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL27791864 | 0.91 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL6686007 | 0.90 | MEN1 (0.41) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL1508329 | 0.88 | MEN1 (0.39) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL546382 | 0.86 | — | — | |
| Morpholine SCHEMBL2808231 | 0.86 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2808233 | 0.86 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28072685 | 0.86 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL7100628 | 0.84 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL15789448 | 0.84 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL15789446 | 0.84 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6764613-B2 | FOR USE IN BLEACHING AND CLEANING | MID-AMERICA COMMERCIALIZATION CORPORATION | 2004-07-20 | — | — | US | claimed |
| EP-1036070-B1 | N-ALKYL AMMONIUM ACETONITRILE SALTS, METHODS THEREFOR AND COMPOSITIONS THEREWITH | CLOROX CO (US) | 2004-02-18 | — | — | EP | claimed |
| US-20030080319-A1 | N-alkyl ammonium acetonitrile salts, methods therefor and compositions therewith | THE CLOROX COMPANY | 2003-05-01 | — | — | US | claimed |
| EP-1036070-A4 | N-ALKYL AMMONIUM ACETONITRILE SALTS, METHODS THEREFOR AND COMPOSITIONS THEREWITH | CLOROX CO (US) | 2001-01-31 | — | — | EP | claimed |
| EP-1036070-A1 | N-ALKYL AMMONIUM ACETONITRILE SALTS, METHODS THEREFOR AND COMPOSITIONS THEREWITH | The Clorox Company (US) | 2000-09-20 | — | — | EP | claimed |
| WO-1998023602-A1 | N-ALKYL AMMONIUM ACETONITRILE SALTS, METHODS THEREFOR AND COMPOSITIONS THEREWITH | THE CLOROX COMPANY (US) | 1998-06-04 | — | — | WO | claimed |
| US-20040067863-A1 | Enclosed bleach activators | SPECKMANN HORST-DIETER (DE) | 2004-04-08 | — | — | US | disclosed |
| US-6407045-B1 | CLEANING DISHES BY FORMING AQUEOUS CLEANING SOLUTION WITH A SOLID DETERGENT; CONTACTING A DISH SURFACE IN NEED OF CLEANING WITH A CLEANING- EFFECTIVE AMOUNT OF THE CLEANING SOLUTION | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-06-18 | — | — | US | disclosed |
| US-20020032139-A1 | Particulate acetonitrile derivatives as bleach activators in solid detergents | NITSCH CHRISTIAN (DE) | 2002-03-14 | — | — | US | disclosed |