Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL6559574 | 0.90 | MEN1 (0.46) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL9434759 | 0.88 | MEN1 (0.52) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL1508329 | 0.83 | MEN1 (0.39) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL27791864 | 0.81 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL546382 | 0.81 | — | — | |
| Morpholine SCHEMBL7100628 | 0.79 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL6562102 | 0.77 | L3MBTL1 (0.39) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL10346421 | 0.77 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL10346419 | 0.77 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL9393876 | 0.77 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067863-A1 | Enclosed bleach activators | SPECKMANN HORST-DIETER (DE) | 2004-04-08 | — | — | US | disclosed |
| US-6407045-B1 | CLEANING DISHES BY FORMING AQUEOUS CLEANING SOLUTION WITH A SOLID DETERGENT; CONTACTING A DISH SURFACE IN NEED OF CLEANING WITH A CLEANING- EFFECTIVE AMOUNT OF THE CLEANING SOLUTION | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-06-18 | — | — | US | disclosed |
| US-20020032139-A1 | Particulate acetonitrile derivatives as bleach activators in solid detergents | NITSCH CHRISTIAN (DE) | 2002-03-14 | — | — | US | disclosed |