Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 11/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603299 | 0.91 | KCNE1 (0.54) | KCNE1KCNQ1MAOBARALDH1A1 | |
| SCHEMBL6559382 | 0.84 | MAPT (0.45) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6559918 | 0.82 | TRPV1 (0.38) | KCNE1KCNQ1ALDH1A1MAPTHTT | |
| SCHEMBL6560799 | 0.81 | HTR2B (0.42) | ALDH1A1MAPTHTTTAAR1HTR2B | |
| SCHEMBL6559231 | 0.80 | KCNE1 (0.52) | KCNE1KCNQ1MAOBCTSDBACE1 | |
| SCHEMBL6559509 | 0.80 | TRPV1 (0.45) | KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL6601126 | 0.80 | KCNE1 (0.68) | KCNE1KCNQ1MAOBARALDH1A1 | |
| SCHEMBL6560806 | 0.79 | KCNA5 (0.44) | CTSDBACE1BACE2 | |
| SCHEMBL8481843 | 0.78 | KCNE1 (0.52) | KCNE1KCNQ1MAOBALDH1A1MAPT | |
| SCHEMBL8481853 | 0.78 | KCNE1 (0.54) | KCNE1KCNQ1MAOBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906911-B1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6177449-B1 | CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
| EP-0906911-A1 | Sulfonamid-substituted chromane derivatives (K+channel-blocker), process for their preparation, their use as drugsand pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-07 | — | — | EP | disclosed |