Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 8/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603299 | 0.84 | KCNE1 (0.54) | KCNE1KCNQ1TRPV1NPC1RAB9A | |
| SCHEMBL7910522 | 0.82 | KCNE1 (0.43) | KCNE1KCNQ1KCNH2PTPN1TRPV1 | |
| SCHEMBL6559231 | 0.81 | KCNE1 (0.52) | KCNE1KCNQ1KCNH2PTPN1TRPV1 | |
| SCHEMBL6935178 | 0.81 | NPC1 (0.44) | KCNE1KCNQ1NPC1RAB9AMEN1 | |
| SCHEMBL7910178 | 0.80 | KCNE1 (0.42) | KCNE1KCNQ1KCNH2PTPN1MTNR1A | |
| SCHEMBL7900359 | 0.79 | KCNE1 (0.41) | KCNE1KCNQ1KCNH2KDM4EALDH1A1 | |
| SCHEMBL6559918 | 0.79 | TRPV1 (0.38) | KCNE1KCNQ1TRPV1KDM4EALDH1A1 | |
| SCHEMBL6559916 | 0.78 | TRPV1 (0.42) | TRPV1SIRT2 | |
| SCHEMBL6559382 | 0.78 | MAPT (0.45) | KCNE1KCNQ1TRPV1MTNR1AMTNR1B | |
| SCHEMBL7470852 | 0.77 | KCNE1 (0.47) | KCNE1KCNQ1KCNH2PTPN1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |