SCHEMBL6559974

SCHEMBL6559974

Nc1ccc(CN2CCCC(=O)C2)cc1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
LMNA P02545 1/20 0.49
HRH3 Q9Y5N1 4/20 0.46
HRH4 Q9H3N8 1/20 0.42
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
KDM4E B2RXH2 1/20 0.41
PARP1 P09874 1/20 0.40
CXCR4 P61073 2/20 0.40
MBTD1 Q05BQ5 1/20 0.40
L3MBTL3 Q96JM7 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HTR6 P50406 1/20 0.39
SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6557748 0.97 ALDH1A1 (0.66) ALDH1A1LMNAHRH3HRH4HDAC1
SCHEMBL6557554 0.90 ALDH1A1 (0.55) ALDH1A1LMNAHRH3KDM4ESIGMAR1
SCHEMBL15500352 0.83 TNIK (0.50) ALDH1A1LMNAHRH3HRH4HDAC1
SCHEMBL568477 0.83 SIGMAR1 (0.53) ALDH1A1HDAC1HDAC6L3MBTL1SIGMAR1
Hydrochloric Acid SCHEMBL1243957 0.81 SIGMAR1 (0.52) ALDH1A1HDAC1HDAC6L3MBTL1SIGMAR1
SCHEMBL1366467 0.81 L3MBTL1 (0.54) LMNAHRH3HRH4CXCR4L3MBTL1
Hydrochloric Acid SCHEMBL2346749 0.80 SIGMAR1 (0.50) ALDH1A1HDAC1HDAC6L3MBTL1SIGMAR1
Hydrogen Peroxide SCHEMBL27308227 0.80 SIGMAR1 (0.50) ALDH1A1HRH3HDAC1HDAC6L3MBTL1
Hydrochloric Acid SCHEMBL16760314 0.80 SIGMAR1 (0.50) ALDH1A1HDAC1HDAC6L3MBTL1SIGMAR1
SCHEMBL17465265 0.80 SIGMAR1 (0.47) ALDH1A1LMNAHRH3HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1436255-A1 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2004-07-14 EP claimed
WO-2003024924-A1 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2003-03-27 WO claimed